Most patients present with slowly progressive pain, with or without a mass. Symptoms arise when the lesion begins to destroy the cortex and irritate the periosteum or when the weakening of the bone caused by the tumor causes pain due to imminent pathologic fracture. Some giant cell tumors present with a pathologic fracture.
Giant cell tumor of bone is a benign lesion that is a usually solitary and locally aggressive. It is believed by some to be potentially malignant. In the very rare instances this lesion has the potential for metastasis to the lungs and in these cases the lung lesions may behave in an indolent fashioned and even require no treatment. The authors recommend a chest CT scan for all patients newly diagnosed with GCT